CD40LG and autoimmune polyendocrinopathy: Urbanski et al. compared the characteristics of APS patients with isolated IgM positivity (aCL or aβ2GPIs) with the non-isolated IgM populations, and they reported that stroke was more frequent in APS patients with isolated APS after adjustment for cardiovascular risk factors (odds ratio, 3.8; 95% CI, 1.3–11.5) [24].