Another common disorder that should not be overlooked is polycystic ovary syndrome (PCOS): women with PCOS have an increased prevalence of cardiovascular risk factors, mostly due to insulin resistance and subclinical CVD markers such as coronary artery calcium score, C-reactive protein, carotid intima-media thickness, and endothelial dysfunction, but it is not entirely clear whether PCOS is an independent predictor of clinical CVD events [94]. The gene discussed is CRP; the disease is polycystic ovary syndrome.