Given the connection among AT-I, nicotine, miR-21, NLRP3, ROS, PTEN, inflammation, and sepsis, we speculate that AT-I may inhibit nicotine-induced septic damage by regulating miR-21, PTEN, and ROS/NLRP3 pathways, which warrants further experiments for verification in the future. This evidence concerns the gene PTEN and Sepsis.