Furthermore, 0.25 mg/kg of genistein and daidzein, s.c. for 4 weeks, reduced anxiety-like behavior in ovariectomized rats without causing significant uterine tissue changes or the expression of uterine ERα and ERβ, while 17β-estradiol reduced anxiety-like behavior but increased the expression of both types of receptors [25]. Here, ESR1 is linked to Anxiety.