↑ TP53-wt vs. TP-mut GBM↑ GBM vs. peritumoral tissue↓ Glioma patients vs. healthy individuals↑ Glioma patients vs. healthy individuals↓ IDH-wt vs. IDH-mut GBM↑ associated with poor OS in grade IV gliomas. This evidence concerns the gene IDH1 and central nervous system cancer.