The authors suggested that the harmful effect of hyperglycemia and LIGHT on pancreatic islet function was through enhancement of endoplasmic reticulum stress, as evidenced by increased secretion of pro-inflammatory cytokines and the release of pro-coagulant mediator tissue factor, which led to pancreatic islet cell apoptosis, and all of this was counteracted by IL-22 which promoted islet cell function and survival. Here, IL22 is linked to Hyperglycemia.