PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Genetic variants in patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), glucokinase regulatory protein (GCKR), and membrane-bound o-acyltransferase 7 (MBOAT7) also increase the risk of MASLD [99].