Previous data from Zamboni and colleagues demonstrated that adults with current anorexia nervosa had a higher proportion of visceral than subcutaneous adipose tissue [98], and, at least in the initial period following weight restoration, subjects presented with increased abdominal obesity [99,100], the normalisation of leptin [101], and an increase in MSNA and urinary noradrenaline, albeit to a resting level that remained lower than that seen in healthy BMI-matched control subjects [95,96]. This evidence concerns the gene LEP and anorexia nervosa.