REN and left ventricular hypertrophy: The observations of Burns and colleagues [237], who showed that combined treatment targeting the sympathetic and renin–angiotensin–aldosterone system provided a greater reduction in left ventricular mass compared with a thiazide diuretic and calcium channel blocker, despite equal blood pressure reduction, provided further support for the engagement of the sympathetic nervous and renin–angiotensin–aldosterone systems in generating left ventricular hypertrophy.