TGFB1 and obesity due to melanocortin 4 receptor deficiency: In addition, picroside II inhibits TGFβ1 transcriptional activity via activation of YY1 to alleviate renal fibrosis [50], liquiritin treats psoriasis by modulating the YY1/RBP3 axis [51], quercetin ameliorates diabetic hepatic lipid accumulation via the mTOR/YY1 pathway [52], berberine protects against endothelial via AMPK/NF-κB/YY1 injury [53], and betaine prevented obesity via miR-378a/YY1 [54].