Given that NLRP3 inflammasome activation and IL-18 production are critical in pancreatic cancer progression [142,143] and considering IL-18’s role as a CXCR1/2 ligand promoting tumorigenesis and angiogenesis [144,145,146,147], 8 represents a promising marine-derived therapeutic candidate. The gene discussed is IL18; the disease is pancreatic neoplasm.