TNF and Parkinson disease: Specifically, the IL-17/TNF pathways directly drive the release of proinflammatory factors and amplify inflammatory signaling [44]; leukocyte transendothelial migration serves as an essential process facilitating the infiltration of inflammatory cells into tissues [45]; focal adhesion modulates the adhesion and migration of inflammatory cells through integrin-mediated mechanisms [46], indicating that Asp G may be associated with inflammatory cascades in PD.