Recent studies have demonstrated that S100A8/A9 plays a primary role in the development of DVT through inducing platelet activation and NET formation, and S100A8/A9 potentiates VWF-dependent platelet agglutination in the presence of ristocetin and contributes to procoagulant platelet formation and thrombosis [9,12]. The gene discussed is VWF; the disease is deep vein thrombosis.