Compound 63 also inhibited Protein Tyrosine Phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 3.6 +/− 0.04 μmol/L in a non-competitive manner, and can be used for treating type 2 diabetes and obesity [73]. Here, PTPN1 is linked to obesity due to melanocortin 4 receptor deficiency.