We also analyzed TCGA and other datasets for muscle-invasive bladder cancer (MIBC) and NMIBC, respectively, for the characterization of DSC3-correlated TII, the relationship of DSC3 with pathologic and molecular subtype of bladder cancer, and the impact of DSC3 expression on treatment outcome and survival to identify potential unmet medical needs in the treatment of bladder cancer. This evidence concerns the gene DSC3 and urinary bladder cancer.