Studies have demonstrated that both acne vulgaris (AV) and hidradenitis suppurativa (HS) share inflammatory pathways that result in immune system dysregulation through enhanced activity of IL-1β, TNF-α, and IL-17 pathways leading to follicular occlusion along with neutrophilic inflammation and abnormal keratinocyte proliferation [8]. Here, TNF is linked to histiocytic sarcoma.