APC and Gardner syndrome: DTs also carry mutations in the Wnt/APC/β-catenin pathway, which controls embryonic and embryonal stem cell development, with sporadic DTs comprising the overwhelming majority (85–90%), demonstrating β-catenin mutations, and inherited forms (10–15%) demonstrating APC mutations as part of Gardner’s syndrome, a subtype of Familial Adenomatous Polyposis [21].