Yeh et al. [16] evaluated UFT maintenance following CCRT in locally advanced HNSCC and reported improvements in OS, DFS, and distant metastasis-free survival (DMFS), while Lien [15] explored biomarker-guided selection using cortactin expression in hypopharyngeal cancer, suggesting a potential role for UFT in molecularly defined subgroups. The gene discussed is CTTN; the disease is hypopharynx cancer.