And the progression-free survival (PFS) period was linked to similar cell subpopulations, with the density of FoxP3+PD-L1+ cells, especially CD8−FoxP3+PD-L1+ cells, in both the tumor and stromal area being a risk factor, and the density of CD8+FoxP3− cells emerging as the most significant protective factor (Figure S10b and Table S8). The gene discussed is CD274; the disease is neoplasm.