As S. aureus small colony variants (SCVs) are relatively common and associated with reduced lung function and increased risk of pulmonary exacerbations in children with CF (21, 22), we also quantified the MIC of ATR-002 on a CF S. aureus normal colony variant (SA0831NCV) strain and an isogenic small colony variant of this strain (SA0831SCV) and discovered that the SA081SCV strain had an MIC of 16 μg/mL, while the NCV was 32 μg/mL (Table 1 and Fig. 1C), suggesting that ATR-002 could also be utilized as a therapy against S. aureus SCV. This evidence concerns the gene ATR and cystic fibrosis.