To determine whether the MEK1/2 inhibitor ATR-002 would elicit an antibacterial effect in Mek2KO mice infected with USA300, bacterial burdens in the lung at 4 hours of infection in Mek2KO mice treated with either vehicle or ATR-002 were quantified, revealing that Mek2KO mice treated with ATR-002 also had a significant reduction in bacterial burden (Fig. S4). This evidence concerns the gene MAP2K1 and infection.