The first known chimeric receptor designed for the treatment of experimental allergic encephalomyelitis (EAE), a mouse model for multiple sclerosis, took advantage of the immunodominant myelin basic protein (MBP) peptide epitope, ranging from amino acids 89–101, which is restricted by Ias and was linked along with Ias to the cytoplasmic domain of the TCR-ζ chain [35]. This evidence concerns the gene MBP and multiple sclerosis.