DDX53 and neoplasm: A comparison of the two types of sdMSNs with different charges (PEG/TA (2:1) and MSN-PEG/TA (1:2)) in the CT26-bearing mouse model showed that the weakly positively charge MSN-PEG-TA (2:1) exhibited excellent tumor accumulation compared with the more positively charged MSN-PEG/TA (1:2).