AGT and hypertensive disorder: The activation of AT1R via binding with angiotensin II (AngII) stimulates diverse intracellular signaling pathways such as phospholipase C (PLC), Ca2+ channels, phospholipase D (PLD), phospholipase A2 (PLA2), adenylate cyclase, MAP kinases (MAPK), the JAK-STAT pathway, and NADPH oxidase through the coupling of G proteins (Gq/11, Gi/0, and G12/13) to the C-terminal of the receptor, which participates in cellular proliferation, fibrosis, apoptosis, and inflammation to facilitate the pathological conditions of hypertension [13].