Using fixed-effect inverse-variance weighted models as our primary analytical approach, our two-sample MR results demonstrated that genetically predicted SMDT1-encoded mitochondrial calcium uniporter regulator levels were significantly associated with increased risks of cardiovascular diseases (OR = 1.06, 95%CI = 1.01–1.10, p = 0.008), coronary atherosclerosis (OR = 1.08, 95%CI = 1.01–1.16, p = 0.027), myocardial infarction (OR = 1.09, 95%CI = 1.01–1.18, p = 0.037), and cardiomyopathy (OR = 1.14, 95%CI = 1.01–1.30, p = 0.033), with all findings visually summarized in Figure 5. This evidence concerns the gene SMDT1 and cardiovascular disorder.