Hippo/YAP pathway: GPC3 knockdown in HCC cells resulted in the down-regulation of both mRNA and protein levels of Yes-associated protein (YAP), and the exogenous addition of YAP-1 can partly rescue the cells from GPC3 knockdown-induced apoptosis as well as restore the decreased capabilities in proliferation, migration, and invasion [78]. The gene discussed is GPC3; the disease is hepatocellular carcinoma.