In contrast, GPC3 is markedly up-regulated in various solid tumors, including hepatocellular carcinoma (HCC), non-small cell lung cancer, testicular and ovarian yolk sac tumors, melanoma, ovarian clear cell carcinoma (OCCA), specific gastric cancer (GC) types, esophageal squamous cell carcinoma (ESCC), testicular germ cell tumors, colorectal cancer, and renal rhabdoid tumors. This evidence concerns the gene GPC3 and hepatocellular carcinoma.