Since dystrophin and YAP compete in binding to the same PPYP motif within the C-terminus of β-dystroglycan, it could be speculated that in DMD, the loss of dystrophin could excessively reinforce the binding between β-dystroglycan and YAP, impairing the nuclear activity of YAP and the cellular functions that arise from it, including autophagy (Figure 4). This evidence concerns the gene DMD and Duchenne muscular dystrophy.