YAP1 and Duchenne muscular dystrophy: Since dystrophin and YAP compete in binding to the same PPYP motif within the C-terminus of β-dystroglycan, it could be speculated that in DMD, the loss of dystrophin could excessively reinforce the binding between β-dystroglycan and YAP, impairing the nuclear activity of YAP and the cellular functions that arise from it, including autophagy (Figure 4).