For example, in the context of chronic lymphocytic leukemia (CLL), iNKT cells are initially implicated in tumor surveillance and can delay the disease onset, but once the disease occurs, they become functionally impaired and their engagement, together with the expression of CD1d by Tcl1-CLL cells, highly correlate with disease progression [22]. Here, CD1D is linked to B-cell chronic lymphocytic leukemia.