CHI3L1 and neoplasm: In colorectal cancer, iNKT cells are aberrantly activated by different tumor-associated bacteria to produce both IL-17 and Granulocyte-macrophage colony-stimulating factors (GM-CSF), consequently recruiting tumor-associated neutrophils (TANs), or chitinase 3-like-1 protein (CHI3L1), impairing cell lytic machinery [23,51].