Exerting a similar pro-tumor activity on iNKT cells, Porphyromonas gingivalis (Pg), an opportunistic oral pathogen previously associated with different inflammatory diseases and cancers, hampers the iNKT cell lytic machinery through increased expression of chitinase 3-like-1 protein (CHI3L1) [51]. This evidence concerns the gene CHI3L1 and neoplasm.