Nrf2 enhances the differentiation-promoting ability of carnosic acid (CA, a plant-derived polyphenolic antioxidant) when co-administered with 1α,25-dihydroxyvitamin D3 (1,25D) in AML cells via the upregulation and activation of activator protein-1 (AP-1) and the vitamin D receptor [123]. This evidence concerns the gene JUN and acute myeloid leukemia.