Transfecting MLL-AF9 (low-H2O2 phenotypes) into recipient mice, they found that the development of leukemia in these was faster compared to leukemia models transduced with granulocyte-macrophage progenitors (GMPs) or hematopoietic stem cells (HSCs), thus indicating that redox metabolism (but not the pluripotency state) may be important in promoting leukemogenesis. This evidence concerns the gene MLLT3 and leukemia.