In cancer cell lines with constitutive Nrf2 accumulation (A549, H2126, LK2, and EBC1 cells), Yoichiro Mitsuishi et al. showed that Nrf2 activates genes whose products are involved in TKT, phosphogluconate dehydrogenase (PGD), G6PD, TALDO1, and PPP [54]. This evidence concerns the gene PGD and cancer.