Transfecting MLL-AF9 (low-H2O2 phenotypes) into recipient mice, they found that the development of leukemia in these was faster compared to leukemia models transduced with granulocyte-macrophage progenitors (GMPs) or hematopoietic stem cells (HSCs), thus indicating that redox metabolism (but not the pluripotency state) may be important in promoting leukemogenesis. The gene discussed is KMT2A; the disease is leukemia.