Primarily, the effects of high-MYC expression by neoplastic meibocytes on the ISR were not evaluated to determine whether these trends are conserved in the context of malignancy; however, work to evaluate the ISR in three primary human ocular adnexal sebaceous gland carcinoma cell lines to elucidate how the MYC-ISR axis affects meibocyte proliferation, tumorigenesis, and apoptosis is ongoing [5]. This evidence concerns the gene MYC and sebaceous adenocarcinoma.