Knock-out phenotype observed for the master regulator of HSP proteins, HSF1.HSF1 knock out (Hsf1tm1Ijb/Hsf1tm1Ijb) in female mice causes infertility (J:58383, J:65267); abnormal female meiosis and abnormal meiotic spindle assembly checkpoint (J:175085). The gene discussed is HSF1; the disease is Infertility.