It has also been reported that Nrf2 is the key regulator in iron and lipid peroxidation-dependent cell death, known as ferroptosis [56]; we tested the combination of dauricine (15 μM) with RSL3 (ferroptosis inducer) on A549 and H1975 cells related to lung adenocarcinoma (Supplementary Figures S2 and S3). The gene discussed is NFE2L2; the disease is lung adenocarcinoma.