Specifically, membrane-type matrix metalloproteinase 1 (MT1-MMP) cleaves pro-MMP-2 through its catalytic domain, converting it into active MMP-2 (64 kDa), which degrades components of the ECM, including collagen and fibronectin, and participates in cytoskeletal remodeling, promoting the formation of pseudopodia, ultimately enhancing the invasiveness of tumor cells [41,42]. The gene discussed is MMP2; the disease is neoplasm.