NFKB1 and cancer: Possible explanations are that in some contexts, including cancer, activation of NF-κB is compromised by failure of the Rela (also known as p65, encoded by Rela) subunit in CD8+ T cells [26], or that CD8+ T cell responses can be modulated indirectly by Treg cells, which are also activated by NF-κB signaling [27].