VCP and amyotrophic lateral sclerosis: Third, misfolded proteins, including defective ribosomal proteins (DRiPs) can accumulate inside SGs and other types of biomolecular condensates, including PML nuclear bodies and nucleoli, converting them into an aggregated state; this process is prevented by the action of the HSP70 and HSP90 chaperones, as well as by the valosin-containing protein (VCP), whose mutations are associated with ALS-FTD [252,262,263,264].