TARDBP and amyotrophic lateral sclerosis: This suggests a broad role of TDP-43 in guaranteeing mRNA stability, maturation and transport [56,150,151,152], with important consequences spanning from the development of neuronal cells in the early stages of embryogenesis [115], to the maintenance of the neuromuscular junctions (NMJs), which progressively degenerate in ALS-FTD cases that show TDP-43 pathology [153,154,155].