SMARCA4 and germ cell tumor: Tumors arising in midline locations should raise suspicion for NUT-rearranged, SMARCB1-deficient, or SMARCA4-deficient tumors.2 These tumors, traditionally associated with squamous histology, can mimic poorly differentiated or dedifferentiated tumors, such as germ cell tumors with IHC and NGS necessary for differentiation.