ABCB11 and cholestasis: These models allow high-throughput screening of cholestaticdrugs and provide mechanistic insights by linking cholestasis to theinhibition of transporters like BSEP,−,  multidrug resistance-associatedprotein 3 (MRP3),, and 4 (MRP4),, and sodium (Na+) taurocholate cotransporting polypeptide(NTCP)., However, in vitro modelsoften focus on single parameters which may not fully capture the complexityof DIC.