Li et al. reported that in a mouse model of cholestasis-induced fibrosis,S1P and S1P3 receptor expression were upregulated in liver tissue.Jackson et al. further elucidated howbile acids and sphingolipids regulate hepatic lipid metabolism andnoted the dysregulation of these pathways in conditions such as steatosis,inflammation and fibrosis in patients with Nonalcoholic Fatty LiverDisease (NAFLD). Here, MBTPS1 is linked to cholestasis.