CASP3 and ischemia: In line with the findings of our experimental study, numerous reports in the literature have highlighted the neuroprotective properties of sugammadex across different ischemia-reperfusion models.33, 36 In the cerebral ischemia-reperfusion model of Ciftci et al.,36 it is documented that the caspase-3 apopptotic cell numbers that increase due to ischemia-reperfusion damage were significantly reduced by sugammadex application.