To test their potency as inhibitors of TTR fibril formation, the15 ligands were evaluated for their ability to inhibit the mechano-enzymaticmechanism of fibrillogenesis of V122I TTR, which is one of the mostcommon amyloidogenic variants,, causing a disease withseverity intermediate between the wild-type and other rare, more aggressivetypes of amyloidosis. As shown in Table , most of the moleculesdirectly derived from compound 1 after modification in the linker(B1, B2, B4, B4A) were excellent inhibitors of fibrillogenesis. This evidence concerns the gene TTR and amyloidosis.