SMAD7 and hepatocellular carcinoma: There are many known differences between these cell lines, e.g.: miR-122 level is high in Huh7 while low in FLC4 (known data, validated by us experimentally; data not shown); low levels of TGF-beta & Smad7, and sensitivity to TGF-beta-induced cytostasis in Huh7, while high levels of TGF-beta & Smad7, and resistance to TGF-beta-induced cytostasis in FLC4 [64]; different spectrum of proteins induced by UVC-irradiated apoptotic FLC4 cells compared with other tested HCC cell lines, including Huh7 [65].