MYC and cancer: A large number of transcription factors are targeted substrates of HATs, including oncogenes and tumor suppressor genes associated with tumorigenesis, such as MYC and TP53. Myc protein, which is encoded by the gene c-MYC, is one of the most abundant oncogene proteins in cancer, and is stabilized by GCN5 with an acetylation modification at Lys323 (Patel et al., 2004).