HDAC11 negatively regulated the expression of interleukin-13/17 (IL-13/17) and tumor necrosis factor-alpha (TNF-α) in Hodgkin lymphoma, suggesting that HDAC11 inhibitors killed tumor cells by activating inflammatory responses, immune system activity, and apoptosis processes (Buglio et al., 2011). This evidence concerns the gene TNF and neoplasm.