In this review, we propose a preliminary recommendation for a unified WHO‐ICC classification of five AML subtypes: AML with PML::RARA rearrangement, AML with NPM1 mutation, AML with KMT2A rearrangement, AML with MECOM rearrangement, and AML with in‐frame bZIP CEBPA. The gene discussed is NPM1; the disease is acute myeloid leukemia.