Of the remaining 4 patients, 2 with silent corticotroph adenomas had increases in testosterone (median 77% [range 57-97%]), and 1/2 (50%) had reductions in IGF-1 SD (median change −21.5% [range −50-93%], median absolute change [IQR] −0.05 [N/A]), 1 patient with a colloid cyst had an increase in TT by 60% and a reduction in IGF-1-SD by 42% (absolute change −1.2-SD), and the final patient with a Rathke cleft cyst had an increase in TT by 8.4% and a reduction in IGF-1-SD by 39% (absolute change −1.2-SD). This evidence concerns the gene IGF1 and ACTH-producing pituitary gland adenoma.