HSP90 is a chaperone protein that regulates protein maturation and is involved in the regulation of atherosclerotic lesions through various pathways, such as lipid metabolism disorders (Zheng et al., 2019), vascular smooth muscle cell proliferation and migration (Fu et al., 2019), glucocorticoid receptor axis (Profumo et al., 2018), and oxidative stress (Zhang et al., 2017). The gene discussed is HSP90AA1; the disease is Disorder of lipid metabolism.