TP53 and osteonecrosis: Chen et al. (2020) demonstrated that steroid-induced SONFH in rats is associated with increased ROS levels and osteoclast alterations, both of which contribute to the disease’s pathophysiology. Previous studies have established that ROS, iron accumulation, lipid peroxidation, and glutathione depletion are crucial in ferroptosis (Hirschhorn and Stockwell, 2019). Furthermore, recent findings by Sun et al. (2022) showed that dexamethasone induces ferroptosis in glucocorticoid-induced osteonecrosis of the femoral head via the P53/SLC7A11/GPX4 pathway.