While the broader roles of TRIM proteins in host-virus interactions, ubiquitin ligase activity, and antiviral innate immune signaling have been extensively reviewed (van Gent et al., 2018; Hage and Rajsbaum, 2019; Giraldo et al., 2020; Shen et al., 2021), the specific contributions of TRIM domains in viral infections remain less explored. The gene discussed is TRAT1; the disease is viral infectious disease.