ARNi, angiotensin receptor-neprilysin inhibitor; HFrEF, heart failure with reduced ejection fraction; HFmrEF, heart failure with midrange ejection fraction; HFpEF, heart failure with preserved ejection fraction; MRAs, mineralocorticoid receptor antagonists; SGLT2i, sodium-glucose cotransporter 2 inhibitor. The gene discussed is SLC5A2; the disease is heart failure.