Furthermore, the team retrospectively reviewed the clinical data of 193 patients with growth hormone-secreting pituitary adenoma (GHPA) and reported that the tumor sizes of GHPAs with multiple TF positivity were smaller and that these tumors were less invasiveness; however, the rate of hormonal remission was lower than that for GHPAs with only PIT1 positivity (23). This evidence concerns the gene POU1F1 and neoplasm.