Some of the commonly used fasting-based IR indices include Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) (11) and its improved version HOMA2-IR (12), Quantitative Insulin Sensitivity Check Index (QUICKI) (13), Triglyceride/High-Density Lipoprotein (TG/HDL) ratio (14), Triglyceride - Glucose (TyG) index (15), and McAuley index (MCAi) (16). The gene discussed is INS; the disease is Insulin resistance.