CDK4 and breast carcinoma: Transcriptomic profiling of palbociclib-resistant MCF-7 cells reveals upregulated autophagy-related genes and increased autophagosome formation, underscoring ER+ breast cancer’s reliance on autophagy to evade CDK4/6 blockade (Lanceta et al., 2020; Soria-Bretones et al., 2022).