Our analysis identified age (OR 1.055, 95% CI: 1.027–1.084, p < 0.05), BMI (OR 1.194, 95%, CI: 1.104–1.291, p < 0.05), a high TP-ALB ratio (OR 2.615, 95% CI: 1.234–5.540, p = 0.012), the TAAR + David procedure (OR 5.668, 95% CI: 1.359–23.646, p = 0.017) and ventilation duration (OR 1.005, 95%CI: 1.001–1.008, p = 0.005) as independent predictors of AKI severity. The gene discussed is ALB; the disease is acute kidney injury.