It is feasible that contradictory results between the transcriptional expression from GEO database (GSE85195) and the reported protein levels of APC, GSK3B and AXIN, at least in leukoplakia and early stage OSCC, are due to the sequestration of these proteins in early endosomes, leading to stabilization of β-catenin and augmented TCF/LEF-dependent transcription (66). The gene discussed is GSK3B; the disease is leukoplakia.